2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-159698A
    IONIS-DGAT 2Rx sodium
    IONIS-DGAT 2Rx (ION-224) sodium is a DGAT2 inhibitor, which is promising for research of atherosclerosis.
    IONIS-DGAT 2Rx sodium
  • HY-N0666S4
    L-Aspartic acid-13C4 55443-54-4 98.30%
    L-Aspartic acid-13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
    L-Aspartic acid-13C4
  • HY-N0728S3
    α-Linolenic acid-13C18 287111-28-8
    α-Linolenic acid-13C18 is the 13C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
    α-Linolenic acid-13C18
  • HY-N0729S4
    Linoleic acid-d5 1169764-58-2 ≥98.0%
    Linoleic Acid-d5 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism.
    Linoleic acid-d5
  • HY-N0830S4
    Palmitic acid-d2 62689-96-7 ≥98.0%
    Palmitic acid-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
    Palmitic acid-d2
  • HY-W001940
    DL-m-Tyrosine 775-06-4 99.96%
    DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect.
    DL-m-Tyrosine
  • HY-W011082
    NLRP3-IN-2 16673-34-0 ≥98.0%
    NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism.
    NLRP3-IN-2
  • HY-W062836
    BAY 41-8543 256498-66-5 99.94%
    BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.
    BAY 41-8543
  • HY-12778
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride 1246638-08-3 99.63%
    N-Demethyl Ivabradine Hcl is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
  • HY-19663
    Lemildipine 94739-29-4 99.58%
    Lemildipine is a new dihydropyridine calcium entry blocker.
    Lemildipine
  • HY-B0484
    Buflomedil hydrochloride 35543-24-9 99.81%
    Buflomedil hydrochloride, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders.
    Buflomedil hydrochloride
  • HY-B0930
    Efloxate 119-41-5 99.73%
    Efloxate (Angorlisin) is a vasodilator used in the research of chronic coronary insufficiency and angina pectoris. Efloxate binds to Staphylococcus aureus sortase A.
    Efloxate
  • HY-B1061
    Nicotinic acid N-oxide 2398-81-4 99.92%
    Nicotinic acid N-oxide can be used for research on hyperlipidemia.
    Nicotinic acid N-oxide
  • HY-B1182
    Chromocarb 4940-39-0 99.51%
    Chromocarb is a synthetic vasoprotectant.
    Chromocarb
  • HY-B1399
    3-Methylsalicylic acid 83-40-9 ≥98.0%
    3-Methylsalicylic acid is a salicylic acid derivative that acts on human plasma and has significant fibrinolytic activity by activating the fibrinolytic system.
    3-Methylsalicylic acid
  • HY-N5100
    Isodemethylwedelolactone 350681-33-3 99.81%
    Isodemethylwedelolactone is a kind of procoagulant and haemolytic constituent isolated from Eclipta alba.
    Isodemethylwedelolactone
  • HY-N8223
    Viscumneoside III 118985-27-6 ≥98.0%
    Viscumneoside III, a dihydroflavone O-glycoside, is a potent tyrosinase inhibitor with an IC50 of 0.5 mM. Viscumneoside III has anti-angina pectoris.
    Viscumneoside III
  • HY-103262
    PSB069 78510-31-3 99.5%
    PSB069 bearing a p-chlorophenylamino residue is a potent, well-tolerated and nonselective NTPDases1, 2, 3 inhibitor(Ki=16~18 μM).
    PSB069
  • HY-141636
    1-PalMitoyl-2-arachidoyllecithin 35418-58-7 ≥99.0%
    1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.
    1-PalMitoyl-2-arachidoyllecithin
  • HY-144390
    (S)-S007-1558 1327156-14-8 99.78%
    (S)-S007-1558 (compound 5) is a glycoprotein VI (GPVI) platelet receptor antagonist. (S)-S007-1558 inhibits collagen-induced platelet aggregation with an IC50 of 25.3 μM.
    (S)-S007-1558
Cat. No. Product Name / Synonyms Application Reactivity